15A1 Biopharmaceuticals Protein Crystallography

Abstract

Biological Crystallography (BX, MX, PX) is a technique used to determine the 3-dimensional structures of biological molecules such as proteins, viruses and nucleic acids (RNA and DNA) to a resolution higher than ~5 Angstrom. From the studies of this structural information, the detailed mechanism of the biological functions carried out by those macromolecules in living cells and organisms can be elucidated. The x-rays deflected ("scattered") by a single crystal of biological molecules concentrate into sharp intense spots (crystal diffraction pattern), and the structure of the biological molecule can be determined by analysis of the intensities and positions of the diffraction spots.

Areas of Research

Multiple-Wavelength Anomalous Dispersive and Monochromatic Protein Crystallography

Light Source

TypeSuperconducting Multipole Wiggler
Source SizeHorizontal αh = 0. mm
Vertical αv =  0. mm
Period Length6.1 cm
Magnetic Field3.1 T
Energy Range5.6 ~ 15.5 keV (2.21 Å ~ 0.8 Å)

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 Contacts

Endstation

+886-3-578-0281 Ext. 1151

BL Spokesperson

Jean, Yuch-Cheng (簡玉成)
ycjean@nsrrc.org.tw
+886-3-578-0281 Ext. 7321

BL Manager/Local Contact

Chiang, Cheng-Hung (姜政宏)
jjh@nsrrc.org.tw
+886-3-578-0281 Ext. 7369


Techniques

  • X-ray Photoelectron Spectroscopies (XPS)

Disciplines

  • Biochemistry

General Information

  • Source: 15A1
  • Energy Range: 10~1700 ev
  • Focused Spot Size: XX
  • Status: Operational







National Synchrotron Radiation Research Center

101 Hsin-Ann Road, Hsinchu Science Park, Hsinchu, Taiwan 30076

+886-3-578-0281