14A1 BM - IR Microscopy

Infrared Microspectroscopy ES

The TLS 14A IR beamline was designed to extract mid-infrared radiation for FTIR microspectroscopy studies, collecting 70 x 30 mrad2 (H x V) of the radiation generated by a bending magnet of Taiwan Light Source (TLS) storage ring of 1.5 GeV, covering spectral range of 4000-400 cm-1 (2.5 - 25.0 micron in wavelength). The highly collimated beam provides high lateral resolution and which is especially suitable for measurements on micron-sized samples.

The optics of the beamline consists of a plane mirror (M1), two polynomial mirrors (M2 and M3), and several steering and collimating mirrors (M4 and M5 are parabolic and plane mirrors, respectively.), designed by using SHADOW ray tracing simulation [1]. Mirror M1 is water-cooled and made of explosion-bonded Glidcop/ stainless-steel substrate, located 1.22 meters from the arc source of bending magnet. Mirror M1 is with a centered slot for transmitting the X-rays radiation trapped by a water-cooled beam dump, installed with its manipulator inside of chamber of the bending magnet. Mirrors M2 and M3 are high-order polynomial bendable to effectively and precisely focus the infrared radiation from extended arc source of the bending magnet [2-5] at the same location at the downstream beam path for the focused spot by applying stresses against the short-side of mirrors M2 and M3, respectively, to alter the focus length for each of M2 and M3 as illuminated in the Figure 1.

The end-station includes FTIR Spectrometer and Infrared microscope. The beamline is currently set up for multidisciplinary studies.

Figure 1. The optical layout of the NSRRC TLS 14A IR beamline.

Parameters of Light Source

Type1.23 Tesla Bending Magnet
Beam Spot Size< 15 micron (diffraction limited)
Energy Range4000-400 cm-1 (2.5-25.0 micron; 0.5-0.05 eV)
Brilliance (brightness)1 x 1016 (photons/sec/mm2/mrad2/200mA/0.1%BW)

Areas of Research

Material science [6-31], earth and environmental science [32-53], paleontology [54-57] and medical science [58-74]


    1. B. Lai and F. Cerrina, Nucl. Instr. and Meth., A246, 337 (1986).
    2. C.-I. Chen, Y.-C. Lo and K.-L. Tsang, “Optical Design and Construction of Mid-infrared beamline at SRRC”, SRRC/RBM/IM/99-06
    3. Y.-C. Lo, C.-I. Chen, C.-H. Chang, “Applications of synchrotron‐based Fourier transform infrared microspectroscopy technology”, Instruments Today126, 63-71 (2002)
    4. Y.-C. Lee, C.-I Chen, P.-Y. Huang, C.-Y Liu, “A study of Fourier-Transform infrared Microspectroscopy under Top-Up Injection Operation at NSRRC”, Instruments Today170, 7-15 (2009)
    5. Y.-C. Lee, P.-Y. Huang, Y.-C. Chang and C.-I. Chen, “An infrared kinetic study of wax physisorption for oral cavity cancer detection using synchrotron-based infrared microspectrscopy”, Instruments Today170, 47-60 (2009)
    6. Lu, H. C., Whang, W. T., & Cheng, B. M. (2010). Effect of alkyl position of pyrrole on structures and properties of conjugated polysquaraines. Synthetic Metals160(9-10), 1002-1007.
    7. Lu, H. C., Whang, W. T., & Cheng, B. M. (2010). Switchable structural modification accompanying altered optical properties of a zwitterionic polysquaraine. Chemical Physics Letters500(4-6), 267-271.
    8. Taufany, F., Pan, C. J., Rick, J., Chou, H. L., Tsai, M. C., Hwang, B. J., ... & Chen, C. I. (2011). Kinetically controlled autocatalytic chemical process for bulk production of bimetallic core–shell structured nanoparticles. Acs Nano5(12), 9370-9381.
    9. M. Bahou, Y.-J. Wu, and Y.-P. Lee, “A New Method for Investigating Infrared Spectra of Protonated Benzene (C6H7+) and Cyclohexadienyl Radical (c-C6H7) Using Para-hydrogen”, J. Chem. Phys., 136, 154304 (2012). (IF:2.997)
    10. Y.-H. Wu, K.-C. Hsu, and C.-H. Lee, “Characterization of Fe-doped Lithium Aluminosilicate Glass-ceramic Materials by Synchrotron Radiation Techniques”, J. Ceram. Soc. Jpn., 120, 420 (2012). (IF: 1.108)
    11. H.-F. Chen and Y.-J. Wu*, “Structure, Stability, and Vibrational Fundamentals of Low-lying Isomers of C6H7+”, Comput. Theo. Chem., 1006, 100 (2013). (IF: 1.344)
    12. M.Bahou, Y.-J. Wu*, and Y.-P. Lee*, “Formation and Infrared Absorption of Protonated Naphthalenes (1-C10H9+ and 2-C10H9+) and Their Neutral Counterparts in Solid Para-hydrogen”, Phys. Chem. Chem. Phys. 15, 1907 (2013). (IF: 3.567)
    13. P.-Q. Yu, K. Theodoridou, H. Xin, P.-Y. Huang, Y.-C. Lee, B. R. Wood, J. Agric. Food Chem. 61, 7234(2013) (IF:2.906)
    14. L. Luo, J. Lv, C. Xu, and S. Zhang*, “Strategy for Characterization of Distribution and Associations of Organobromine Compounds in Soil Using Synchrotron Radiation Based Spectromicroscopies”, Anal. Chem. 86, 11002 (2014). (IF: 6.350)
    15. M. Tsuge*, M. Bahou, Y.-J. Wu, L. Allamandola, and Y.-P. Lee*, “Infrared Spectra of Ovalene (C32H14) and Hydrogenated Ovalene (C32H15) in Solid Para-hydrogen”, Phys. Chem. Chem. Phys. 18, 28864 (2016). (IF: 3.567)
    16. M.-H. Lin, S. Hy, C.-Y. Chen, J.-H. Cheng, J. Rick, N.-W. Pu, W.-N. Su, Y.-C. Lee and B.-J. Hwang*, “Resilient Yolk-Shell Silicon-Reduced Graphene Oxide/Amorphous Carbon Anode Material Achieved by a Synergistic Dual-Coating Process for Lithium-Ion Batteries”, ChemElectroChem 10.1002/celc.201600254 (2016). (IF: 3.506)
    17. W.-T. Chuang*, Y.-M. Hsu, E.-L. Lin, I.-M. Lin, Y.-S. Sun*, Y.-W. Chiang, C.-J. Su, Y.-C. Lee, and U.-S. Jeng, “Live Templates of a Supramolecular Block Copolymer for the Synthesis of Ordered Nanostructured TiO2 Films via Guest Exchange”, ACS Appl. Mater. Interfaces 8, 33221 (2016). (IF: 8.456)
    18. Tsuge, M., Bahou, M., Wu, Y. J., Allamandola, L., & Lee, Y. P. (2016). Infrared spectra of ovalene (C 32 H 14) and hydrogenated ovalene (C 32 H 15˙) in solid para-hydrogen. Physical Chemistry Chemical Physics, 18(41), 28864-28871.
    19. C.-W. Chen, W.-J. Syu, T.-C. Huang, Y.-C. Lee, J.-K. Hsiao, K.-Y. Huang, H.-P. Yu, M.-Y. Liao and P.-S. Lai*,” Encapsulation of Au/Fe3O4 nanoparticles into a polymer nanoarchitecture with combined near infrared-triggered chemo-photothermal therapy based on intracellular secondary protein understanding”, J. Mater. Chem. B, 5, 5774 (2017) (IF: 4.543)
    20. Y.-H. Hsieh, J.-H. Zhang, W.-C. Chuang, K.-H. Yu, X.-B. Huang, Y.-C. Lee, and C.-I. Lee* , “An in Vitro Study on the Effect of Combined Treatment with Photodynamic and Chemical Therapies on Candida Albicans”,Int. J. Mol. Sci. 19 , 337 (2018). (IF: 4.183)
    21. W.-J. Syu, C.-C. Huang, J.-K. Hsiao, Y.-C. Lee, Y.-T. Huang, P. Venkatesan, and P.-S. Lai*, “Co-precipitation Synthesis of Near-infrared Iron Oxide Nanocrystals on Magnetically Targeted Imaging and Photothermal Cancer Therapy via Photoablative Protein Denature”, Nanotheranostics 3, 236 (2019). (IF: 8.063)
    22. Huang, C. L., Wang, P. Y., & Li, Y. Y. (2020). Fabrication of electrospun CO2 adsorption membrane for zinc-air battery application. Chemical Engineering Journal395, 125031.
    23. I-M. Lin, C.-M. Chou, M.-C. Li, R.-H. Guo, C.-K. Lee, H.-J. Li, Y.-W. Chiang, Y.-H. Lin, Y.-C. Lee, C.-J. Su, U.-S. Jeng, W.-T. Chuang*, “Superhelices with tunable twisting power directed from supramolecular pairing of focal asymmetry in achiral dendron‐jacketed block copolymers” J. Mater. Chem. C, 8, 1923-1932 (2020) (IF: 6.641)
    24. R-H. Guo, C.-M. Chou, C.-C. Wang, M.-J. Deng, J.-M. Lin, C.-Y. Chen, Y.-C. Lee, Y.-W. Chiang, W.-T. Chuang, “Biomimetic strategies for 4.0 V all-solid-state flexible supercapacitor: Moving toward eco-friendly, safe, aesthetic, and high-performance devices”, Chemical Engineering Journal, 414, 128842(2021) (IF: 10.652)
    25. Sahu, R. S., Dubey, A., & Shih, Y. H. (2021). Novel metal-free in-plane functionalized graphitic carbon nitride with graphene quantum dots for effective photodegradation of 4-bromophenol. Carbon182, 89-99.
    26. S. Sahu*, Y.-H. Shih*, and W.-L. Chen, “New Insights of Metal Free 2D Graphitic Carbon Nitride for Photocatalytic Degradation of Bisphenol A”, J. Hazard. Mater., 402 , 123509 (2021) (IF: 9.038)
    27. Chu, A. C., Sahu, R. S., Chou, T. H., & Shih, Y. H. (2021). Magnetic Fe3O4@ TiO2 nanocomposites to degrade bisphenol A, one emerging contaminant, under visible and long wavelength UV light irradiation. Journal of Environmental Chemical Engineering9(4), 105539.
    28. K. Lakshmanan, W.-H. Huang, S. A. Chala, B. W. Taklu, E. A. Moges, J.-F. Lee, P.-Y. Huang, Y.-C. Lee, M.-C. Tsai*, W.-N. Su*, and B. J. Hwang*, “Highly Active Oxygen Coordinated Configuration of Fe Single-atom Catalyst toward Electrochemical Reduction of CO2 into Multi-carbon Products”, Adv. Funct. Mater., 32(24), 2109310 (2022) (IF: 19.924) (citation:3)
    29. Ayele, A. A., Tsai, M. C., Adam, D. B., Awoke, Y. A., Huang, W. H., Chang, C. Y., ... & Hwang, B. J. (2022). Electrochemical oxidation of ethylene glycol on TiO2-supported platinum single-atom catalyst into valuable chemicals in alkaline media. Applied Catalysis A: General646, 118861.
    30. Chen, P. L., Chang, T. Y., Chen, P. S., Chan, A. H. Y., Rosyadi, A. S., Lin, Y. J., ... & Liu, C. H. (2023). Van der Waals heterostructure mid-infrared emitters with electrically controllable polarization states and spectral characteristics. ACS nano17(11), 10181-10190.
    31. Li, K. C., Wu, Z. H., Ke, C. H., Lee, Y. C., Lee, J. F., Chen, J. M., ... & Liaw, W. F. (2023). Selectivity and activity modulation of electrocatalytic carbon dioxide reduction by atomically dispersed dual iron catalysts. Journal of Materials Chemistry A11(5), 2377-2390.
    32. Reza, A. S., Jean, J. S., Lee, M. K., Liu, C. C., Bundschuh, J., Yang, H. J., ... & Lee, Y. C. (2010). Implications of organic matter on arsenic mobilization into groundwater: evidence from northwestern (Chapai-Nawabganj), central (Manikganj) and southeastern (Chandpur) Bangladesh. Water research44(19), 5556-5574.
    33. Nath, B., Maity, J. P., Jean, J. S., Birch, G., Kar, S., Yang, H. J., ... & Chatterjee, D. (2011). Geochemical characterization of arsenic-affected alluvial aquifers of the Bengal Delta (West Bengal and Bangladesh) and Chianan Plains (SW Taiwan): implications for human health. Applied Geochemistry26(5), 705-713.
    34. Selim Reza, A. H. M., Jean, J. S., Yang, H. J., Lee, M. K., Hsu, H. F., Liu, C. C., ... & Lee, C. Y. (2011). A comparative study on arsenic and humic substances in alluvial aquifers of Bengal delta plain (NW Bangladesh), Chianan plain (SW Taiwan) and Lanyang plain (NE Taiwan): implication of arsenic mobilization mechanisms. Environmental geochemistry and health33, 235-258.
    35. Kar, S., Maity, J. P., Jean, J. S., Liu, C. C., Nath, B., Lee, Y. C., ... & Li, Z. (2011). Role of organic matter and humic substances in the binding and mobility of arsenic in a Gangetic aquifer. Journal of Environmental Science and Health, Part A46(11), 1231-1238.
    36. Mostafa, M. G., Chen, Y. H., Jean, J. S., Liu, C. C., & Lee, Y. C. (2011). Kinetics and mechanism of arsenate removal by nanosized iron oxide-coated perlite. Journal of Hazardous Materials187(1-3), 89-95.
    37. S.-E. Peng*, C.-S. Chen, Y.-F. Song, H.-T. Huang, P.-L. Jiang, W.-N. U. Chen, L.-S. Fang and Y.-C. Lee*, “Assessment of metabolic modulation in free-living versus endosymbiotic Symbiodinium using synchrotron radiation-based infrared microspectroscopy” Biol. Lett. 8(3), 434-437 (2012) (IF:3.651)
    38. A. H. M. S. Reza, J.-S. Jean, M.-K. Lee, T. R. Kulp, H.-F. Hsu,C.-C. Liu, Y.-C. Lee, “The binding nature of humic substances with arsenic in alluvial aquifers of Chianan Plain, southwestern Taiwan” Journal of Geochemical Exploration, 114,  98–108 (2012).(IF:1.312)
    39. C.-C. Liu, S. Kara, J.-S. Jean, C.-H. Wang, Y.-C. Lee, O. Sracek, Z. Li, J. Bundschuh, H.-J. Yang, C.-Y. Chen, “Linking geochemical processes in mud volcanoes with arsenic mobilization driven by organic matter”, Journal of Hazardous Materials, 262, 980– 988 (2013). (IF:4.553)
    40. A. Kunz*, B. A. Walther, L. Löwemark, and Y.-C. Lee, “Distribution and Quantity of Microplastic on Sandy Beaches along the Northern Coast of Taiwan”, Mar. Pollut. Bull. 111, 126 (2016). (IF: 3.782)
    41. Weng, Y. T., Wang, C. C., Chiang, C. C., Tsai, H., Song, Y. F., Huang, S. T., & Liang, B. (2018). In situ evidence of mineral physical protection and carbon stabilization revealed by nanoscale 3-D tomography. Biogeosciences, 15(10), 3133-3142.
    42. Luo, L., Lv, J., & Chen, Z. (2018). Synchrotron infrared microspectroscopy reveals the roles of aliphatic and aromatic moieties in sorption of nitroaromatic compounds to soils. Science of the total environment, 624, 210-214.
    43. J. Rathod, J.-S. Jean, W.-T. Jiang, I-H. Huang, B. H. Liu, Y.-C. Lee, Science of the Total Environment, 669, 527–539 (2019). (IF: 5.589)
    44. L. J. Bancina, B. A. Walther, Y. -C Lee, A. Kunz, “Two-dimensional distribution and abundance of micro- and mesoplastic pollution in the surface sediment of Xialiao Beach, New Taipei City, Taiwan”, Marine Pollution Bulletin 140, 75-85(2019), (IF: 3.782)
    45. Y-T. Weng, J. Rathod, B. Liang*, C.-C. Wang, Y. Iizuka, N. Tamura, C.-L. Chen, Y.-C. Lee , “Black carbon enriches short-range-order ferrihydrite in Amazonian Dark Earth: Interplay mechanism and environmental implications”, Science of The Total Environment, 725,10, 138195 (2020) (IF: 5.589)
    46. Y-L. Cho, Y.-C. Lee, L.-C. Hsu, C.-C. Wang, P.-C. Chen, S.-L. Liu, H.-Y. Teah, Y.-T. Liua, Y.-M. Tzoua, “Molecular mechanisms for Pb removal by Cyanidiales: a potential biomaterial applied in thermo-acidic conditions”, Chemical Engineering Journal, 401, 125828 (2020) (IF: 10.652)
    47. Y.-S. Chen, Y.-C. Lee, and B. A. Walther*, "Microplastic Contamination of Three Commonly Consumed Seafood Species from Taiwan: A Pilot Study", Sustainability, 12, 9543 (2020). (IF: 2.576) (citation:2)
    48. Yan, Y. S., Chen, Y. H., Wang, C. C., Hwu, Y., Lee, Y. C., Sheu, H. S., & Chiang, C. C. (2021). Faults caused by the fault: Microstructural and mineral characterization of deformation in Chungliao Tunnel, Taiwan, caused by Chishan Fault. Engineering Geology292, 106245.
    49. S,-W. Chang, R.-G. Chen, T.-H. Liu, Y.-C. Lee, C.-S. Chen, T.-S. Chiu and C.-Y. Ko, “Dietary Shifts and Risks of Artifact Ingestion for Argentine Shortfin Squid Illex argentinus in the Southwest Atlantic”, Front. Mar. Sci., 8:675560 (2021). doi: 10.3389/fmars.2021.675560 (IF: 4.912)
    50. Cheng, Y., Sun, H., Yang, E., Lv, J., Wen, B., Sun, F., ... & Liu, Z. (2021). Distribution and bioaccessibility of polycyclic aromatic hydrocarbons in industrially contaminated site soils as affected by thermal treatment. Journal of Hazardous Materials411, 125129.
    51. P. Biswas, B. Liang*, G. Turner-Walker 2, J. Rathod, Y.-C. Lee, C.-C. Wang, C.-K. Chang, “Systematic Changes of Bone Hydroxyapatite along a Charring Temperature Gradient: An integrative Study with Dissolution Behaviour”, Science of The Total Environment, 766, 142601(2021) (IF: 6.551) (citation:1)
    52. P. P. Biswas, G. Turner-Walker, J. Rathod, B. Liang*, C.-C. Wang, Y.-C. Lee, and H.-S. Sheu, “Sustainable Phosphorus Management in Soil Using Bone Apatite”, J. Environ. Manage. 305, 114344 (2022) (IF: 8.91) (citation:4)
    53. Y.-L. Cho, Y.-M. Tzou, C.-C. Wang, Y.-C Lee, L.-C. Hsu, S.-L. Liu, A. Assakinah, Y.-H. Chen, N. A. T. Than, Y.-T. Liu*, J. Rinklebe, “Removal and concurrent reduction of Cr(VI) by thermo-acidophilic Cyanidiales: a novel extreme biomaterial enlightened for acidic and neutral conditions”, J. Hazard. Mater., 455:130334, ISSN 0304-3894 (2022), https://doi.org/10.1016/j.jhazmat.2022.130334. ( IF: 12.5)
    54. R. R. Reisz*, T. D. Huang, E. M. Roberts, S. R. Peng, C. Sullivan, K. Stein, A. R. H. LeBlanc, D. Shieh, R. S. Chang, C. C. Chiang, C. Yang, and S. Zong, “Embryology of Early Jurassic Dinosaur from China with Evidence of Preserved Organic Remains”, Nature 496, 210 (2013). (IF: 43.070)
    55. k. S. Brink*, R. R. Reisz*, A. R. H. LeBlanc, R.-S. Chang, Y.-C. Lee, C.-C. Chiang, T. Huang, and D. C. Evans, “Developmental and evolutionary novelty in the serrated teeth of theropod dinosaurs”, Scientific Reports 5, Article number: 12338, (2015). (IF: 5.578)
    56. Y.-C. Lee*, C.-C. Chiang, P.-Y. Huang, C.-Y. Chung, T. D. Huang, C.-C. Wang, C.-I. Chen, R.-S. Chang, C.-H. Liao, R. R. Reisz*, “Evidence of preserved collagen in an Early Jurassic sauropodomorph dinosaur revealed by synchrotron FTIR microspectroscopy”, Nature Communications, 8, 14220, (2017). (IF: 12.124)
    57. Chiu CT, Cao JK, Wang PW, Wu YN, Lee YC, Jeng YR, Shieh DB*, Reisz RR*, "Mammalian tooth enamel functional sophistication demonstrated by combined nanotribology and synchrotron radiation FTIR analyses". iScience. 2023;26(1):105679.
    58. Hsieh, Y. H., Liu, S. J., Chen, H. W., Lin, Y. K., Liang, K. S., & Lai, L. J. (2010). Highly sensitive rare cell detection based on quantum dot probe fluorescence analysis. Analytical and bioanalytical chemistry396, 1135-1141.
    59. Aitken, J. B., Carter, E. A., Eastgate, H., Hackett, M. J., Harris, H. H., Levina, A., ... & Lay, P. A. (2010). Biomedical applications of X-ray absorption and vibrational spectroscopic microscopies in obtaining structural information from complex systems. Radiation Physics and Chemistry79(2), 176-184.
    60. H.-Y. Cheng, L.-J. Lai, and F.-H. Ko, “Rapid and Sensitive Detection of Rare Cancer Cells by the Coupling of Immunomagnetic Nanoparticle Separation with ELISA Analysis”, Int. J. Nanomed. 7, 2967 (2012). (IF: 4.471)
    61. L.-F. Chiu, P.-Y. Huang, W.-F. Chiang, T.-Y. Wong, S.-H. Lin, Y.-C. Lee*, D.-B. Shieh*, “Oral cancer diagnostics based on infrared spectral markers and wax physisorption kinetics”, Anal. Bioanal. Chem. 405(6), 1995-2007(2013) (IF:3.841)
    62. Chen, C. K., Chang, M. H., Wu, H. T., Lee, Y. C., & Yen, T. J. (2014). Enhanced vibrational spectroscopy, intracellular refractive indexing for label-free biosensing and bioimaging by multiband plasmonic-antenna array. Biosensors and Bioelectronics60, 343-350.
    63. C.-K. Chen, M.-H. Chang, H.-T. Wu, Y.-C. Lee, T.-J. Yen, “Enhanced vibrational spectroscopy, intracellular refractive indexing for label-free biosensing and bioimaging by multiband plasmonic-antenna array”, Biosens. Bioelectron., 60, 343 (2014). (IF: 6.451)
    64. H.-Y. Cheng, F.-H. Ko, and L.-J. Lai*, “Using Novel Method to Detect Different Cancer-cell Stages of Model Human Lung Carcinoma”, J. Clin. Lab. Anal. 29, 285 (2015). (IF: 1.728)
    65. C.-H. Lee, C.-Y. Hsu, P.-Y. Huang, C.-I. Chen, Y.-C. Lee*, and H.-S. Yu*, “Arsenite Regulates Prolongation of Glycan Residues of Membrane Glycoprotein: A Pivotal Study via Wax Physisorption Kinetics and FTIR Imaging”, Int. J. Mol. Sci., 17, 427 (2016). (IF: 3.257)
    66. Priprem, Y.-C. Lee, W. Limphirat, S. Tiyaworanant, K. Saodaeng, J. Chotitumnavee, N. Kowtragoon, “Eucalyptus ash alters secondary protein conformation of human grey hair and facilitates anthocyanin dyeing” PLoS ONE 13(7): e0199696 (2018) (IF: 2.806)
    67. Uthaiwat, A. Priprem, S. Chio-Srichan, C. Settasatian, Y.-C. Lee, P. Mahakunakorn, P. Boonsiri, C. Leelayuwat, P. Tippayawat, P. Puthongking and J. Daduang, “Oral Administration of Melatonin or Succinyl Melatonin Niosome Gel Benefits 5-FU-Induced Small Intestinal Mucositis Treatment in Mice.” AAPS PharmSciTech., 22, 200 (2021). https://doi.org/10.1208/s12249-021-01941-y (IF: 2.451)
    68. Uthaiwat, J. Daduang*, A. Priprem, C. Settasatian, S. Chio-Srichan, Y.-C. Lee, P. Mahakunakorn, and P. Boonsiri, “Topical Melatonin Niosome Gel for the Treatment of 5-FU-induced Oral Mucositis in Mice“, Curr. Drug Deliv., 18, 199 (2021) (IF: 1.582)
    69. R. Kumar, Y.-H. Hsu, T.T.T. Vi, J.-H.S. Pang, Y.-C. Lee, C.-H. Hsieh, S.J. Lue, “Graphene Oxide-Induced Protein Conformational Change in Nasopharyngeal Carcinoma Cells: A Joint Research on Cytotoxicity and Photon Therapy” Materials, 14,1396 (2021) (IF: 3.057)
    70. K. Astani, S. Ersali, Y.-C. Lee, P.-J. Lin, Y.-C. Huang, P.-Y. Huang, V. Jafarian, S. Hosseinkhani, C.-J. Chen*,” Determination and evaluation of secondary structure content derived from calcium-induced conformational changes in wild-type and mutant mnemiopsin 2 by synchrotron-based Fourier-transform infrared spectroscopy”, BBA - Proteins and Proteomics, 1868, 140528 (2020) (IF: 2.540)
    71. S-I. Chan*, P. Chuankhayan, P. K. R. Nareddy, I.-K. Tsai, Y.-F. Tsai, K. H.-C. Chen, S. S.-F. Yu*, and C.-J. Chen*, “Mechanism of Pyrroloquinoline Quinone-dependent Hydride Transfer Chemistry from Spectroscopic and High-resolution X ray Structural Studies of the Methanol Dehydrogenase from Methylococcus capsulatus (Bath)”, J. Am. Chem. Soc., 143 , 3359 (2021) (IF: 14.612)
    72. P.-Y. Lin, P.-Y. Huang, Y.-C Lee* and C.-S. Ng*, “Analysis and comparison of protein secondary structures in the rachis of avian flight feathers”, PeerJ, 10:e12919 (2022), http://doi.org/10.7717/peerj.12919 ( IF: 3.06)
    73. Y.-T.Chen, P.-Y.Huang, J.-Y.Wang, Y.-C Lee* and C.-Y. Chai*, “An innovative diagnosis in gastrointestinal neuroendocrine neoplasms using Wax-Physisorption-Kinetics-based FTIR Imaging” Sci. Rep., 12, 17168 (2022). https://doi.org/10.1038/s41598-022-22221-0 ( IF: 4.39)
    74. Yi-Ting Chen#, Pei-Yu Huang#, Chee-Yin Chai, Sebastian Yu, Yu-Lin Hsieh, Hao-Chao Chang, Chin-Wei Kuo, Yao-Chang Lee* and Hsin-Su Yu*, “Early detection of the initial stages of LED light-triggered non-alcoholic fatty liver disease by wax physisorption kinetics-Fourier transform infrared imaging”,  Analyst.148(3):643-653.(2023) doi: 10.1039/d2an01546c.( IF: 5.227 )


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